Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus

Effective Chikungunya Virus-like Particle Vaccine Produced in Insect Cells

The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLPs) in insect cells using recombinant baculoviruses. This well-established expression system is ra...

Inactivated African Horse Sickness Virus Cell Culture Vaccine

Zika virus-like particle (VLP) based vaccine

The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders. The impact of sexual transmission is unclear but raises further concerns about virus dissemination. No specific treatment or vaccine is currently available, thus the development of a safe and effective vaccine is paramount. Here we describe...

Inactivated Whole Virus Influenza A (H5N1) Vaccine1

To the Editor: Avian infl uenza viruses of the H5N1 subtype represent a potential source of the next pandemic (1,2). Our goal was to determine the safety and immunogenicity of a newly developed vaccine in humans. The vaccine was produced by the same method as the interpandemic in-fl uenza vaccine " FluvalAB " used in Hungary for the past 11 years (3,4). The method has been validated by meeting ...

Comparative Efficacy of Feline Leukemia Virus (FeLV) Inactivated Whole-Virus Vaccine and Canarypox Virus-Vectored Vaccine during Virulent FeLV Challenge and Immunosuppression

Four vaccines for feline leukemia virus (FeLV) are available in the United States. This study's purpose was to compare the efficacy of Nobivac feline 2-FeLV (an inactivated, adjuvanted whole-virus vaccine) and PureVax recombinant FeLV (a live, canarypox virus-vectored vaccine) following FeLV challenge. Cats were vaccinated at 9 and 12 weeks with Nobivac feline 2-FeLV (group A, n = 11) or PureVa...